Bone Abstracts

The co-chaperone protein, Bcl-2-associated athanogene 1 (BAG-1) is expressed ubiquitously in bone including cells of the osteoblast-lineage and, plays an important role in cell proliferation, apoptosis and differentiation by regulating signalling and transcription. The study aims to elucidate the function of BAG-1 in osteoblast development by examining differences in osteogenic differentiation of bone marrow stromal cells (BMSCs) from Bag-1+/−</sup...

BAG-1 interacts with diverse proteins including heat shock proteins (HSC70/ HSP70) and nuclear hormone receptors to modulate cell proliferation, differentiation and apoptosis. We have shown that bone marrow stromal cells (BMSCs) of Bag-1+/− female mice display reduced BMP-2-directed osteogenic differentiation potential. Estradiol binds to estrogen receptors (ERs) and is functionally involved in BMP-directed osteogenic differentiation of osteoprogenito...

see P62....

The co-chaperone, Bcl-2-associated athanogene-1 (BAG-1), is expressed by chondrocytes and osteogenic cells, and interacts via heat shock chaperones (HSC70/HSP70) with diverse proteins such as nuclear hormone receptors to regulate cell proliferation, differentiation and apoptosis. Early embryonic lethality in Bag-1 null mice has limited the investigation of the function of BAG-1 in skeletal development. The present study aimed to elucidate the role of BAG-1 in skeletal...